Cord blood and Tissue in the Treatment of Disease

Cord blood is an FDA-approved treatment for nearly 80 diseases including numerous types of malignancies, anemias, inherited metabolic disorders and deficiencies of the immune system. It has saved thousands of lives around the world through more than 40,000 transplantations. The majority of these cord blood transplantations have been performed in patients younger than 18 years of age; however, with advancements in regenerative medicine, it is foreseeable that individuals of all ages can benefit from stem cell therapies in the near future. Transplantations are characterized as either autologous (used by the baby) or allogeneic (used by a matching sibling or other family member).

In addition to the FDA-approved treatments, researchers are looking into other diseases cord blood can treat. Promising research that could potenitally impact a countless numbers of lives is being conduct in the treatment of autism, cerebral palsy, adult stroke and more. Below is a partial list of diseases currently being researched or treated using stem cells like those found in cord blood and cord tissue:

 

Cord Blood Stem Cell Treatments in Clinical Trials

Diagnosis
(Odds)
Possible use by the baby (autologous) Possible use by sibling or other family member (allogeneic)
Acquired Hearing Loss
Learn More
(1 in 8 Children 6–19 in U.S.)
 
Autism
Learn More
(1 in 68 Children in U.S.)
Cerebral Palsy
Learn More
(1 in 300 Children 5–10 in U.S.)
Congenital Heart Defects
Learn More
(1% of births each year in U.S.)
 
Crohn's Disease
Learn More
(0.006% of U.S. population)
Diabetes
Learn More
(9% of U.S. population)
Eczema
Learn More
(13% of Children in U.S.)
 
Parkinson's
Learn More
(0.3% of U.S. population )
Signs of Ageing
Learn More
Stroke
Learn More
(1 in 20,000 before 19 in U.S.)
Tramatic Brain Injury
Learn More
(No. 1 Cause of Childhood Death in U.S.)
 

Cord Tissue Stem Cell Treatments in Clinical Trials

Diagnosis
(Odds)
Possible use by the baby (autologous) Possible use by sibling or other family member (allogeneic)
Amyotrophic Lateral Sclerosis (ALS)
Learn More
(1 in 1,000 in U.S.)
Alzheimer's
Learn More
(50% of those 85 and Older in U.S.)
Cartilage Injury
Learn More
Cleft Palate Repair
Learn More
(1 out of 1,000 Births in U.S.)
Heart Disease
Learn More
(Leading Cause of Death in U.S.)
Lupus
Learn More
(Affects 1 of 250 in U.S.)
Multiple Sclerosis
Learn More
(Affects 1 of 750 in U.S.)
Parkinson's
Learn More
(0.3% of U.S. population)
Rheumatoid Arthritis
Learn More
(~1% of U.S. population)
Spinal Cord Injury
Learn More
Stroke
Learn More
(1 in 20,000 before 19 in U.S.)
Wound Healing
Learn More
 

Full List of FDA-Approved Cord Blood Treatments

Diagnosis Possible use by the baby (autologous) Possible use by sibling or other family member (allogeneic)
Leukemias
(60,000 Diagnoses Each Year)
Acute Lymphoblastic Leukemia  
Acute Myelogenous Leukemia  
Acute Biphenotypic Leukemia  
Acute Undifferentiated Leukemia  
Acute Lymphoblastic Leukemia  
Acute Myelogenous Leukemia (AML)  
Chronic Lymphocytic Leukemia (CLL)  
Juvenile Chronic Myelogenous Leukemia (JCML)  
Juvenile Myelomonocytic Leukemia (JMML)  
Refractory Anemia (RA)  
Refractory Anemia with Ringed Sideroblasts (RARS)  
Refractory Anemia with Excess Blasts (RAEB)  
Refractory Anemia with Excess Blasts in Transformation (RAEB-T)  
Chronic Myelomonocytic Leukemia (CMML)  
Lymphomas
(80,000 Diagnoses Each Year)
Hodgkin’s Lymphoma
Anemias
Aplastic Anemia  
Congenital Dyserythropoietic Anemia  
Fanconi Anemia  
Paroxysmal Nocturnal Hemoglobinuria (PNH)  
Inherited Red Cell Abnormalities
Beta Thalassemia Major (also known as Cooley’s Anemia)  
Blackfan-Diamond Anemia  
Pure Red Cell Aplasia  
Sickle Cell Disease  
Inherited Platelet Abnormalities
Amegakaryocytosis / Congenital Thrombocytopenia  
Glanzmann Thrombasthenia  
Inherited Immune System Disorders
SCID with Adenosine Deaminase Deficiency (ADA-SCID)  
SCID which is X-linked  
SCID with absence of T & B Cells  
SCID with absence of T Cells, Normal B Cells  
Omenn Syndrome  
Kostmann Syndrome  
Ataxia–Telangiectasia  
Bare Lymphocyte Syndrome  
Common Variable Immunodeficiency  
DiGeorge Syndrome  
Leukocyte Adhesion Deficiency  
Lymphoproliferative Disorders (LPD)  
Lymphoproliferative Disorder, X-linked (also known as Epstein–Barr Virus Susceptibility)  
Wiskott–Aldrich Syndrome  
Myeloproliferative Disorders
Acute Myelofibrosis  
Agnogenic Myeloid Metaplasia (Myelofibrosis)  
Polycythemia Vera  
Essential Thrombocythemia  
Phagocyte Disorders
Chediak–Higashi Syndrome  
Chronic Granulomatous Disease  
Neutrophil Actin Deficiency  
Reticular Dysgenesis  
Bone Marrow Cancers
Multiple Myeloma  
Plasma Cell Leukemia  
Waldenstrom’s Macroglobulinemia  
Inherited Immune & Other System Disorders
Cartilage–Hair Hypoplasia  
Gunther’s Disease (Erythropoietic Porphyria)  
Hermansky–Pudlak Syndrome  
Pearson’s Syndrome  
Shwachman–Diamond Syndrome  
Systemic Mastocytosis  
Inherited Metabolic Disorders
Mucopolysaccharidoses (MPS)  
Hurler’s Syndrome (MPS–IH)  
Scheie Syndrome (MPS–IS)  
Hunter’s Syndrome (MPS–II)  
Sanfilippo Syndrome (MPS–III)  
Morquio Syndrome (MPS–IV)  
Maroteaux–Lamy Syndrome (MPS–VI)  
Sly Syndrome, Beta–Glucuronidase Deficiency (MPS–VII)  
Mucolipidosis II (I–cell Disease)  
Adrenoleukodystrophy (ALD)/Adrenomyeloneuropathy (AMN)  
Krabbe Disease (Globoid Cell Leukodystrophy)  
Metachromatic Leukodystrophy  
Pelizaeus–Merzbacher Disease  
Gaucher Disease  
Niemann–Pick Disease  
Sandhoff Disease  
Tay–Sachs Disease  
Wolman Disease  
Lesch–Nyhan Syndrome  
Osteopetrosis  
Solid Tumors
Neuroblastoma  
Medulloblastoma  
Retinoblastoma  

Want to learn about cord blood banking? Click the button to learn everything you need to know.