An Introduction to Cord Tissue

Umbilical cord blood and cord tissue are rich in two distinct types of stem cells. Both types of stem cells play key roles in maintaining our health and each works in its unique way.
 
The CORD TISSUE or Wharton’s jelly is the tissue surrounding the umbilical vein and vessels in the cord. When the vessels are removed you have tissue remaining which contains stem cells termed mesenchymal stem cells or MSCs. MSCs are unique and powerful stem cells that help repair and heal the body in different ways than cord blood. The surrounding tissue is also a rich source of other cell types, which have different potential uses.
 
Mesenchymal stem cells have many unique functions including the ability to inhibit inflammation following tissue damage, secrete growth factors that aid in tissue repair, and differentiate into many cell types including neural cells, bone cells, fat cells and cartilage. 

Why Should I Store Cord Tissue and Cord Blood Stem Cells?

MSCs collected from cord tissue have the ability to regenerate and differentiate into many different types of cells and therefore, they can potentially be used to treat more conditions than cord blood alone can treat.40 MSCs are increasingly being utilized in regenerative medicine for a wide range of conditions including heart and kidney disease, ALS, wound healing and autoimmune diseases.
 
Many new studies show that regenerative medicine is most effective with a mix of stem cell types (simulating the team work taking place within our organs and tissues). MSC’s have been used in clinical trials to complement the cord blood stem cells in the same transplant.41, 42
 
As awareness grows of the future potential uses of MSCs and other cord tissue cells, so too does the number of families preserving both cord blood and cord tissue. Umbilical cord tissue banking is now commonplace, with over 60% of Cryo-Cell’s customers electing to store both.

Cord Tissue Processing

Cryo-Cell International provides the service to collect, test, process and cryopreserve the cord tissue for potential future therapeutic use. The cord tissue banking process begins with the procurement of approximately six inches of the umbilical cord tissue at time of birth, after the cord is cut, cord blood collected, and placenta delivered. The segment of the cord is cleansed, cut and placed in a container containing antibiotics for transport to the laboratory. The cord tissue collection is safe and may be collected in both vaginal and cesarean section births. The container will be transported along with the cord blood for immediate processing once it reaches the laboratory.
 

Storing cord tissue with Cryo-Cell International

More Stem Cells When You Store with Cryo-Cell
Cryo-Cell Process Description
Stores an entire segment of umbilical cord tissue Multiple cell types are stored for potential future therapies:
Mesenchymal stem cells
Endothelial cells
Perivascular cells
Growth factors & proteins
Epithelial cells
All 6 regions are stored: 
Wharton’s jelly
Intervascular region
Perivascular region 
Sub-amniotic region
Blood vessels
Amniotic epithelium
Stored in as many as 6 cryo-vials Allows the potential for multiple therapeutic treatments
Samples can be thawed independently at different times
 Our quality process All of Cryo-Cell's cord blood and tissue processes are in accordance with Good Manufacturing Practice (cGMP), and AABB and FACT/Netcord (The Foundation of Accredited Cellular Therapies) accredited.

Stem Cells You Can Count On

Cryo-Cell International’s processing method provides the most flexibility for the future use of cord tissue stem cells. Cord tissue stem cells are cryopreserved in their natural environment and then extracted immediately before expected use. Certain other cord blood banks extract the stem cells from the tissue through enzymatic digestion before cryopreservation.43 Unlike other companies who extract only the MSC’s from cord tissue, Cryo-Cell International stores the umbilical cord tissue in its entirety to preserve multiple cell types that may be beneficial in future cell therapies for your baby and family.
 
NOT ALL BLOOD BANKS ARE CREATED EQUAL
Cryo-Cell International Other Cord Blood Banks
Cryo-Cell’s cord tissue processing method preserves as many cell types as possible to maximize parents’ future health options. Should future cell therapies be developed using any of the cord tissue cell types, Cryo-Cell International families will have stored these relevant cells.
 
By isolating the stem cells prior to cryopreservation, these cord blood banks may be discarding some of the other types of stem cells. 
Because Cryo-Cell International stores cord tissue in up to 6 vials, cord tissue stem cells may be used in multiple therapeutic treatments and thawed at different times. Processing methods may not comply with future FDA guidelines. That means that these precious cord tissue stem cells, when actually needed for treatment, may be deemed unusable due to processing protocols that are not universally accepted today and may not be universally acceptable in the future.
 
The latest research points to the critical importance of storing the cord tissue prior to processing in order to provide the best possible chance the cord tissue stem cells will be acceptable if needed for a wider range of treatments and clinical applications.
 
 

Cryo-Cell International’s cord tissue cryopreservation processing method has been independently acknowledged as the best in the industry.  According to scientific data published in the October, 2015 issue of Placenta,
 
"…it seems that umbilical cord tissue cryopreservation appears to be the optimal solution for umbilical cord tissue MSCs storage for future clinical use because the cryopreservation of the previously isolated and expanded cells using unstandardized protocols can be considered non compliant in relation to future accepted standards."44
 


Cord Tissue Stem Cells Will Play a Key Role in Regenerative Medicine

Stem cells derived from cord tissue are being utilized in regenerative medicine for a wide range of conditions and are currently being investigated in hundreds of clinical trials. While the research is in its early stages, the possibilities are extremely promising. By banking your baby’s umbilical cord blood and tissue stem cells today, you increase his or her access to these treatments in the future. For more information on these clinical trials, visit  http://clinicaltrials.gov.
 
Current clinical trials include
ALS (Lou Gehrig’s Disease) Lupus
Alzheimer’s Muscular Dystrophy
Aplastic anemia Multiple Sclerosis
Autism Myocardial infarction
Cardiomyopathy Osteoarthritis
Cartilage repair Parkinson’s
Cerebral Palsy Rheumatoid arthritis
Crohn’s Disease Spinal cord injuries
Connective tissue diseases Stroke
Diabetes Traumatic optic neuropathy
Liver failure Ulcerative colitis
Lung injury Wounds, burns, ulcers
 
The potential use of cord tissue stem cells for regenerative applications and to treat debilitating diseases is steadily increasing. Parents want to know they can count on the stem cells they have stored if they are ever needed. Cryo-Cell International umbilical cord tissue cryopreservation insures future clinical use in the event they are ever needed.
 

In order to preserve more types and quantity of umbilical cord stem cells and to maximize possible future health options, Cryo-Cell’s umbilical cord tissue service provides expectant families with the opportunity to cryogenically store their newborn’s umbilical cord tissue cells contained within substantially intact cord tissue. Should umbilical cord tissue cells be considered for potential utilization in a future therapeutic application, further laboratory processing may be necessary. Regarding umbilical cord tissue, all private blood banks’ activities for New York State residents are limited to collection, processing, and long-term storage of umbilical cord tissue stem cells. The possession of a New York State license for such collection, processing and long-term storage does not indicate approval or endorsement of possible future uses or future suitability of these cells.